August 21, 2025 – Thursday

Welcome – Service Instructions

Prof. Dr. José Antonio Sanches

8:30 AM - 8:40 AM

Block 1

Fundamentals of Oncology:

Evolution of cancer treatments: from cytotoxic chemotherapy to targeted therapies and immunotherapy;
Impact of these changes on the profile of skin toxicities;
Main classes of treatments: mechanisms and associated toxicities;
Importance of dermatological evaluation in cancer patients;
Severity classification tools: CTCAE.

Prof. Dr. José Antonio Sanches

8:40 AM - 9:00 AM

Targeted Therapy-Induced Papulopustular Eruption and Other Adverse Events of EGFR Blockade – “PRIDE”:

Definition and clinical importance of papulopustular eruption (preference for the current term);
Associated drugs: EGFR, MEK, HER2, mTOR inhibitors, among others;
Pathophysiology: pilosebaceous follicle dysfunction and cutaneous dysbiosis;
Typical clinical picture and differential diagnosis;
Practical management: prophylaxis, topical and systemic treatments;
Other alterations in the spectrum of the blockade – PRIDE (Papulopustular and Paronychia / Abnormal hair regulation / Itching / Dryness / EGFRi).

Dr. Jade Cury

9:00 AM - 9:30 AM

Hand-Foot Syndrome, Hand-Foot Reaction and Nail Changes:

Fundamental difference between Hand-Foot Syndrome (erythrodysesthesia) and Hand-Foot Reaction associated with targeted therapies;
Drugs related to each entity;
Pathophysiology, clinical presentation and differential diagnosis;
Management: prevention, topical therapies, dose adjustment;
Nail changes induced by cancer treatment: paronychia, onycholysis, melanonychia;
Strategies for managing nail changes.

Dr. Adriana Pessoa Mendes

9:30 AM - 10:00 AM

Questions and Discussion

10:00 AM - 10:15 AM

Interval

10:15 AM - 10:45 AM

Block 2

Alopecia Induced by Oncological Treatments

Chemotherapy-induced anagen alopecia: pathophysiology, clinical features and management.
Persistent post-chemotherapy alopecia (PCIA): diagnosis, risk factors and therapeutic options.
Alopecia induced by targeted therapies: presentations and management.
Alopecia associated with hormone therapy: characteristics and management.
Immune-induced alopecia: autoimmune pathophysiology, clinical features (areata-like, cicatricial) and management.
Preventive strategies: scalp cooling, minoxidil, psychological support.

Dr. Vanessa D Andretta Tanaka

10:45 AM - 11:15 AM

Immune-Induced Cutaneous Adverse Events

Diagnosis and Management of Skin Reactions to Treatments

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